Holger Sondermann, Ph.D.

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Holger Sondermann, Ph.D.
Title
Professor
Department
Deutsches Elektronen-Synchrotron DESY
Institution
CSSB Centre for Structural Systems Biology
Address
Notkestr. 85
City, Pew.Feature.Scholar.Bio.Zip
Hamburg, 22607
Country
Germany
Phone
+49 (0)40 8998 87680
Pew.Feature.Scholar.Bio.Email
[email protected]
Website
https://www.cssb-hamburg.de/research/research_groups/sondermann_group/index_eng.html
Pew.Feature.Scholar.Bio.ResearchField
Microbiology
Pew.Feature.Scholar.Bio.AwardYear
2008

Research

My lab is interested in deciphering the basic regulatory principles in signal transduction networks on a molecular level, focusing on growth factor receptor signaling. In particular, we study the role of scaffolding proteins and other regulators signal transduction in this pathway, using a combination of X-ray crystallography, biophysical and cellular approaches. Scaffolds, which serve as docking hubs for the signaling switches, provide specificity and higher-order control in signaling reactions. Understanding the architecture, mode of action and regulation of these processes will elucidate how cells respond to various inputs producing distinct outputs by using a limited set of molecules.

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