Zhaohui Xu, Ph.D.
![](/-/media/legacy/legacy-and-pre-launch-image-edits/scholars/2001/zhaohui-xu.jpg?la=da&h=180&w=150&hash=0539DBDE62804273379F361C5CE2B4C3)
- Title
- Associate Professor
- Department
- Department of Biological Chemistry
- Institution
- University of Michigan
- Address
-
3163B Life Sciences Institute Box 5606
210 Washtenaw Avenue - City, State, ZIP
- Ann Arbor, MI 48109-2216
- Phone
- (734) 615-2077
- [email protected]
- Website
- http://www.lsi.umich.edu/facultyresearch/labs/xu
- Research field
- Structural Biology
- Award year
- 2001
Research
The goal of our laboratory is to understand the molecular mechanisms by which the cell mediates protein folding and secretion. Despite decades of effort, the protein-folding problem remains one of the most challenging questions in molecular biology. In addition, protein folding inside the cell often faces difficulty, leading to misfolding and aggregation. To overcome these problems, cells have developed sophisticated mechanisms ranging from simple chaperoning, to active folding assistance, to the complex unfolded protein response (UPR). Protein folding problems have been directly linked to many disease states including cystic fibrosis, diabetes, various clotting disorders, and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. We use protein crystallography to study the structures of proteins directly related to in vivo protein folding, secretion and the stress response.
Scholar Keywords
2001 Search Pew Scholars
- Chinfei Chen, M.D., Ph.D.
- Qing C. Chen, M.D., Ph.D.
- Jeffery S. Cox, Ph.D.
- Patricia F. Ducy, Ph.D.
- Michael B. Eisen, Ph.D.
- Douglas J. Epstein, Ph.D.
- K. Christopher Garcia, Ph.D.
- Bruce L. Goode, Ph.D.
- Eva Harris, Ph.D.
- Gustavo W. Leone, Ph.D.
- A. Kimberley McAllister, Ph.D.
- Christopher G. Rongo, Ph.D.
- Yolanda Sanchez, Ph.D.
- Thomas F. Schilling, Ph.D.
- Myung K. Shin, Ph.D.
- P. Todd Stukenberg, Ph.D.
- Song Tan, Ph.D.
- Zhaohui Xu, Ph.D.
- Ebrahim Zandi, Ph.D.
- Gongyi Zhang, Ph.D.