Francis I. Valiyaveetil, Ph.D.

Pew.Feature.Scholar.Bio.Title
Assistant Professor
Pew.Feature.Scholar.Bio.Department
Department of Physiology and Pharmacology
Pew.Feature.Scholar.Bio.Institution
Oregon Health and Science University
Pew.Feature.Scholar.Bio.Address
3181 SW Sam Jackson Park Road
Mail Code L334
Pew.Feature.Scholar.Bio.City, Pew.Feature.Scholar.Bio.State, Pew.Feature.Scholar.Bio.Zip
Portland, OR 97239
Pew.Feature.Scholar.Bio.Phone
(503) 418-0946
Pew.Feature.Scholar.Bio.Email
[email protected]
Pew.Feature.Scholar.Bio.Website
http://www.ohsu.edu/xd/education/schools/school-of-medicine/departments/basic-science-departments/physpharm/faculty-staff/valiyaveetil.cfm
Pew.Feature.Scholar.Bio.ResearchField
Biochemistry
Pew.Feature.Scholar.Bio.AwardYear
2007

Research

We study K+ channels, which are integral membrane proteins that catalyze the selective conduction of K+ ions across biological membranes. While a great deal of research has been focused on these channels, fundamental questions regarding the mechanism of ionic selectivity and gating remain. We have developed a unique combination of methods to address these questions. Our methods include the use of chemical synthesis to introduce precise chemical changes in the channels, x-ray crystallography to determine the structural effects and electrophysiology to determine the functional effects of these changes. Using this multidisciplinary approach we are presently investigating the mechanism of K+ selectivity and the process of slow inactivation.

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