Qing R. Fan, Ph.D.

Sections

Qing R. Fan, Ph.D.
Title
Assistant Professor of Pharmacology and Pathology
Department
Department of Pharmacology
Institution
Columbia University
Address
Physicians & Surgeons
Room 7-430, 630 W 168th Street
City, State, ZIP
New York, NY 10032
Phone
(212) 342-0115
Email
[email protected]
Website
http://sklad.cumc.columbia.edu/pharm/cumc/profile_new.php?id=301
Research field
Structural Biology
Award year
2009

Research

Our laboratory studies the molecular mechanisms by which G-protein coupled receptors (GPCRs) transmit signals across biological membranes. GPCRs represent the superfamily of transmembrane receptors that signal through heterotrimeric G-proteins. GPCRs recognize a diverse array of ligands, and are the targets for 50-60% of clinical drugs. We combine x-ray crystallography with various biochemical techniques to study these receptors with two general goals: (1) to determine the specificity of receptor-ligand interactions, and (2) to identify receptor activation mechanisms.

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