Our lab is interested in the basic mechanisms that regulate growth, the process whereby cells and organisms accumulate mass and increase in size. The pathways that regulate growth are often deranged in human diseases, such as diabetes and cancer. Our long-term goals are to identify and characterize these mechanisms and to understand their roles in the normal and diseased physiology of mammals. Our current focus is on a cellular system called the Target of Rapamycin (TOR) pathway, a major regulator of growth in many eukaryotic species. In addition to our work on growth control, we are developing and applying new technologies that facilitate the analysis of gene function in mammalian cells. We have developed cell-based microarrays that allow us to look at the cellular effects of perturbing the activity of thousands of genes in parallel. We are also a founding member of a consortium of labs in the Boston area that has developed and is using a genome-scale RNA interference (RNAi) library targeting human and mouse genes.