Daniel E. Gottschling, Ph.D.

Pew.Feature.Scholar.Bio.Title
Member
Pew.Feature.Scholar.Bio.Department
Division of Basic Sciences
Pew.Feature.Scholar.Bio.Institution
Fred Hutchinson Cancer Research Center
Pew.Feature.Scholar.Bio.Address
1100 Fairview Avenue N
Mailstop A3-025
Pew.Feature.Scholar.Bio.City, Pew.Feature.Scholar.Bio.State, Pew.Feature.Scholar.Bio.Zip
Seattle, WA 98109-1024
Pew.Feature.Scholar.Bio.Phone
(206) 667-4494
Pew.Feature.Scholar.Bio.Email
[email protected]
Pew.Feature.Scholar.Bio.Website
http://research.fhcrc.org/gottschling/en.html
Pew.Feature.Scholar.Bio.ResearchField
Genetics
Pew.Feature.Scholar.Bio.AwardYear
1991

Research

Our laboratory uses the budding yeast Saccharomyces cerevisiae as a model system to investigate fundamental questions in biology. One of our current areas of interest is understanding the striking link between increasing age and the incidence of cancer in humans. A hallmark of cancer, genomic instability, is observed in all types of organisms including yeast. We recently discovered that as yeast cells enter the middle-to-late period of their replicative lifespan, they switch to a state of high genomic instability that persists until death. We believe this change represents a fundamental transition in many aging cells and thus are taking a number of approaches to understand the mechanism underlying this phenomenon.

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