Carolina G. Lucas, Ph.D.

Title
Postdoctoral Fellow
Department
Immunobiology
Institution
Yale University
Address
300 Cedar St.
City, State, Zip
New Haven, CT 06519
Country
United States
Phone
(203) 785-7662
E-mail
carolina.olucas@gmail.com
Website
https://medicine.yale.edu/lab/iwasaki
Research Field
Immunology; Virology
Award Year
2018
Country Of Origin
Brazil
Mentor Name
Akiko Iwasaki, Ph.D.

Research

In the Iwasaki lab, I will explore the factors that influence the severity of infection with Chikungunya, a virus spread by mosquitoes. For some who become infected, the associated fever and joint pain disappear within a week; others—including infants and the elderly—can develop more severe clinical manifestations, such as debilitating neurological conditions. To determine what makes certain individuals more susceptible to neurological damage, I will use techniques in molecular genetics and virology to develop a mouse model to study the impact of Chikungunya on the brain. I will then assess the role that different types of brain cells—and different types of immune cells—play in disease progression, and determine whether viruses that successfully target the nervous system share a particular molecular signature. This work could foster the development of vaccines or therapeutics that will prevent infection or reduce disease severity.

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