The Catteruccia lab explores ways to combat malaria. Mosquitoes are vectors for a variety of viruses and parasites capable of causing diseases, from Zika to malaria. But some mosquitoes are infected with a bacterium called Wolbachia, which appears to reduce the insects’ ability to harbor disease-causing agents. Because mosquitoes are becoming increasingly resistant to insecticides, I will investigate the use of this bacterium as a novel biological alternative to curb malaria transmission. I will study how infection with Wolbachia affects the fitness, survival, and fertility of Anopheles mosquitoes—as well as their ability to harbor and transmit the parasite that causes malaria. I will then analyze how changes in temperature alter Wolbachia’s effects on the mosquito—results that could expand our ability to use bacteria as a biological tool in the fight against malaria in regions with varied climates.