Enfu Hui, Ph.D.

Title
Assistant Professor
Department
Cell and Developmental Biology
Institution
University of California, San Diego
Address
9500 Gilman Drive, 2222A Pacific Hall, Mail Code 0347
City, State, Zip
La Jolla, CA 92093
Phone
(858) 246-0832
E-mail
enfuhui@ucsd.edu
Website
https://enfuhui.wixsite.com/huilab-ucsd
Research Field
Immunology
Award Year
2018

Research

The Hui lab will dissect the mechanism by which the immune system can be exploited to eradicate cancers. Some tumor cells evade immune detection by binding to PD-1—a receptor that keeps immune cells switched off; drugs that block PD-1 have recently shown promise in treating these cancers. As a postdoctoral fellow, I discovered that PD-1 suppresses immune cell activity by blocking the activation of a stimulatory receptor called CD28. Now, our lab will determine whether and how additional immune “checkpoints” operate in conjunction with PD-1 to block CD28 or other immune receptors, and we will identify the inhibitory molecules these systems recruit to dampen the immune response. Our findings could lead to the development of novel immunotherapeutic agents and could hold the key to treating patients who develop a resistance to inhibitors of PD-1.

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