Martin Latterich, Ph.D.

Research

Our main focus is on understanding disease, such as cancer and genetically caused aging and degenerative disorders, at the systems level. The ultimate goal of this research is to define biomarkers to create better molecular diagnoses and companion diagnostic assays, as well as to understand the pathways and networks affected by disease in an effort to define future drug targets. We use genomic sequencing, epigenomic profiling, RNA profiling, proteomics, and traditional biochemistry and molecular biology to capture the dynamic changes taking place during disease development, followed by genetic and biochemical validation methods in well-defined experimental model systems. Our current interest is in tumorigenesis, the regulation of protein degradation in health and disease, and aging at the molecular level.