Rafik Neme, Ph.D.

Title
Postdoctoral Fellow
Department
Biochemistry & Molecular Biophysics
Institution
Columbia University
Address
7701 W. 168th St
HHSC 714
City, State, Zip
New York, NY 10032
Country
United States
Phone
(212) 305-4680
E-mail
rn2419[at]cumc.columbia.edu
Website
http://biology.columbia.edu/people/landweber
Research Field
Evolutionary Biology
Award Year
2017
Country Of Origin
Colombia
Mentor Name
Laura Landweber, Ph.D.

Research

The Landweber lab investigates how some unusual single-celled organisms can break apart—and correctly reassemble—their chromosomes without making any fatal mistakes. A handful of pond-dwelling organisms keep their DNA in two nuclei—one of which contains DNA that will be fragmented before mating and then pieced back together in the resulting offspring. Using a suite of approaches in molecular, computational, and evolutionary biology, I will compare the genomes of several of these organisms to assess how and when this ability evolved, the molecular components that underlie the process, and how this system influences molecular innovation. These findings will enhance our understanding of how cells maintain genome organization and integrity, a process that often goes awry in human cancers.