Bruno Manta, Ph.D.

Title
Postdoctoral Fellow
Department
Department of Medicine
Institution
Brigham and Women's Hospital
Address
77 Avenue Louis Pasteur
HMS New Research Building, Room 435
City, State, Zip
Boston, MA 02115
Country
United States
Phone
617-525-5122
E-mail
bruno.manta[at]gmail.com
Website
http://gladyshevlab.bwh.harvard.edu/
Research Field
Biochemistry
Award Year
2015
Country Of Origin
Uruguay
Mentor Name
Vadim Gladyshev, Ph.D.

Research

The Gladyshev Lab studies mechanisms of redox regulation of cellular processes involved in physiological and pathophysiological states. Recent research has found that nearly every process in cells is redox controlled, but the major paradigm has been that cellular proteins are oxidized (damaged) by reactive oxygen species or other oxidants in a relatively unspecific way, and reduced (repaired) by designated reductases. Now, using new approaches in biochemistry, molecular and cell biology, I will investigate mechanisms for targeted, specific, reversible redox control and its role in cellular dynamics. These findings will shed light on the novel mechanisms of redox control and could lead to therapeutic interventions in the fields of aging or cancer.