Luisina De Tullio, Ph.D.

Title
Postdoctoral Fellow
Department
Department of Biochemistry and Molecular Biophysics
Institution
Columbia University
Address
650 West 168th Street
Black Building Room 536
City, State, Zip
New York, NY 10032
Country
United States
Phone
(212) 342-2943
E-mail
luisinadetullio[at]fcq.unc.edu.ar
Website
http://thegreenelab.cumc.columbia.edu/ECG%20Home.html
Research Field
Biochemistry
Award Year
2014
Country Of Origin
Argentina
Mentor Name
Eric C. Greene, Ph.D.

Research

The Greene lab investigates how a cell’s DNA repair machinery corrects errors made during DNA replication. When cells copy their chromosomes, replication machinery occasionally makes mistakes. Most of these errors are fixed by a system that removes the faulty nucleotide and replaces it with the correct one, but if missed by the repair machinery the errors can cause diseases such as cancer. Combining biochemical, molecular biology and cell biological methods with a state-of-the-art microscopic technique developed in Dr. Greene’s lab, I will track the movement of repair proteins to see whether they follow on the heels of the replication machinery and whether the replication halts while mistakes are corrected. These findings could provide insights into the biology of cancers that are associated with a failure of this corrective system.