Juan I. Fuxman Bass, Ph.D.

Title
Postdoctoral Fellow
Department
Program in Systems Biology
Institution
University of Massachusetts Medical School
Address
368 Plantation Street AS5.1008
City, State, Zip
Worcester, MA 1605
Country
United States
Phone
(774) 578-2413
E-mail
Juan.FuxmanBass[at]umassmed.edu
Website
http://profiles.umassmed.edu/profiles/ProfileDetails.aspx?From=SE&Person=758
Research Field
Systems Biology
Award Year
2012
Country Of Origin
Argentina
Mentor Name
Dr. Albertha J. Walhout

Research

Cytokines play fundamental roles in the regulation of immune responses against pathogens and were shown to be crucial in several pathological conditions such as autoimmune diseases, immune deficiencies and cancer. Cytokine production is highly regulated and activation of cytokine gene transcription is a key step in inflammatory processes. In fact, cytokine mis-regulation can lead to immune deficiencies, cancer and autoimmune diseases making them appealing therapeutic targets. Even though cytokine regulation has been well studied, little is known about which transcription factors (TFs) bind to their regulatory regions and how they control cytokine expression. To be able to fully comprehend cytokine transcriptional regulation we need to undertake a systems biology approaches that will provide an integrated view of how cytokines are orchestrated during an immune response. Our research aim is to delineate a human cytokine regulatory network. We are identifying the TFs that can bind the promoters and other known regulatory regions for all human cytokines taking advantage of a new enhanced yeast one hybrid assay pipeline recently developed in the Walhout laboratory. We will model the protein-DNA interactions into a gene regulatory network (GRN) depicting the cytokine genes, the TFs and their relationships, and will integrate this GRN with publicly available expression data. Finally, our aim is to determine the regulatory consequences of the physical interactions identified. Our hope is to expand the current knowledge of cytokine regulation which may provide leads to identify new therapeutic targets for multiple immune related diseases.