Guillermo L. Lehmann Mántaras, M.D., Ph.D.

Title
Postdoctoral Fellow
Department
Department of Ophthalmology
Institution
Weill Cornell Medical College
Address
Box 233, Room LC-305
1300 York Avenue
City, State, Zip
New York, NY 10065
Country
United States
Phone
(212) 746-2277
E-mail
gul2008[at]med.cornell.edu
Website
http://www.cornellcelldevbiology.com/boulan/
Research Field
Developmental Biology
Award Year
2011
Country Of Origin
Argentina
Mentor Name
Dr. Enrique J. Rodriguez-Boulan

Research

Vertebrate photoreceptors (PR) are sensory neurons and their physiological role in vision depends on the proper development of the outer segment (OS). We are addressing a central unanswered issue in vision research: the role of retinal pigment epithelium (RPE) in the terminal differentiation of PR. Our central hypothesis is that maturation of the apical surface of RPE, composed of very long apical microvilli (MV) (~20 ?m), is critical for the normal development of PR OS. We are employing an innovative approach that integrates cell biology and genetics and utilizes a novel RPE-PR co-culture model, to address my specific aims. This project has strong potential for major advances in vision research and important implications for human retinal diseases.