Rodrigo Galhardo, Ph.D.

Title
Associate Professor
Department
Department of Microbiology
Institution
University of Sao Paulo
Address
Av Prof. Lineu Prestes, 1374 CVAT116
City
Sao Paulo
Country
Brazil
E-mail
rgalhard[at]usp.br
Research Field
Genetics
Award Year
2006
Country Of Origin
Brazil
Mentor Name
Susan M. Rosenberg, Ph.D.

Research

In our lab we focus on several aspects of DNA repair and mutagenesis, using the model organism Caulobacter crescentus and the power of bacterial molecular genetics. We are working on the physiological role of Y family DNA polymerases, error-prone enzymes involved in DNA damage tolerance and mutagenesis. These enzymes act to tolerate insults to the DNA by promoting translesion DNA synthesis, and we are currently investigating the specificity of the two Y-family polymerases of C. crescentus for different DNA lesions. We are also interested in the mutagenesis promoted by such enzymes when using non-damaged DNA, and its regulation by several environmental stresses, such as prolonged stationary phase, antibiotic insult and starvation.

Fellow Keywords