Maximiliano A. D'Angelo, Ph.D.

Title
Assistant Professor
Department
Development, Aging, and Regeneration Program
Institution
Sanford Burnham Medical Research Institute
Address
10901 N. Torrey Pines Road
City, State, Zip
La Jolla, CA 92037
Country
United States
Phone
(858) 795-5385
E-mail
mdangelo[at]sanfordburnham.org
Website
http://www.sanfordburnham.org/talent/Pages/MaximilianoD%E2%80%99Angelo.aspx
Research Field
Cell biology
Award Year
2004
Country Of Origin
Argentina
Mentor Name
Antonio C. Bianco, M.D., Ph.D.

Research

I am interested in understanding the biochemical adaptations involved in energy expenditure that are mediated by thyroid hormone activation. Thyroxine (T4) is a pro-hormone secreted by thyroid gland, which must be activated by deiodination to T3 in order to initiate thyroid action. Its activation is catalyzed by deiodinase 1 and 2 (D1/D2). D2 is considered a critical homeostatic T3-producing deiodinase during adaptation to cold exposure and the enzyme activation seems to be part of a thermogenic program in mouse brown adipocytes. My current research aim is to investigate the biochemical adaptations that are dependent of the thyroid hormone activation. To address this point I am using two models: (i) Goldfish, a fish that is able to survive when exposed at low temperature and in which the importance of thyroid hormone activation is unclear; and (ii) mice, that are used to identify new activators of the D2 enzyme in brown adipocytes and also to search the physiological co-factors of D2 activity. The latter is useful to understand the participation of D2 in certain diseases characterized by disturbances in energy expenditure, such as diet-induced obesity, fasting and type 2 diabetes.