Tomás L. Falzone

Title
Investigator
Department
Department of Histology and Cell Biology
Institution
University of Buenos Aires
Address
Paraguay 2155 3er Piso
Facultad de Medicina, UBA
City
Buenos Aires
Country
Argentina
Phone
05411-5950-9626
E-mail
tfalzone[at]fmed.uba.ar
Website
http://www.ibcn.fmed.uba.ar/200_grupos-lab-transp-axo-enfe-falzone.html
Research Field
Cell biology
Award Year
2002
Country Of Origin
Argentina
Mentor Name
Lawrence Goldstein, Ph.D.

Research

The focus of my lab research is to understand the role of motor proteins in axonal transport and to comprehend how impairments in transport may derive in the manifestation of neurodegenerative diseases such as Alzheimer’s disease. Using fluorescent-tagged cargos we want to understand the axonal transport properties of proteins, vesicles and organelles. This tracking technique used in combination with biochemistry and pathological characterization of motor protein mutant mice are currently used to identify the role of motor proteins in the initiation and progression of pathologies that may arise upon transport defects. The future goal of the laboratory is to generate a neuronal model from human stem cell differentiation to study axonal transport properties in normal conditions and disease.