Giancarlo V. De Ferrari, Ph.D.

Title
Associate Professor
Department
Center for Biomedical Research
Institution
Andres Bello University
Address
P.O. Box 8370134
City
Santiago
Country
Chile
E-mail
gdeferrari[at]unab.cl
Website
http://cib.unab.cl/giancarlo-de-ferrari/
Research Field
Neuroscience
Award Year
2002
Country Of Origin
Chile
Mentor Name
Randall T. Moon, Ph.D.

Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder paralleled by selective neuronal death, which is probably caused by the deposition and neurotoxicity of the amyloid �-peptide (A�). We and others observed that A� neurotoxicity induced loss of function of Wnt signaling components and that activation of this signaling cascade protected post-mitotic neurons from A� neurotoxicity. Therefore, I am interested in understanding the molecular mechanism by which Wnt signaling is lost in cells undergoing A� -dependent degeneration. My research involves integrating basic biological processes of cells exposed to cytotoxic insults, and may offer alternative therapeutic approaches to prevent or treat neurodegenerative diseases.