Ana M. Landeira-Fernandez, Ph.D.

Title
Associate Professor
Department
Center for Health Sciences
Institution
Federal University of Rio de Janeiro
Address
Departamento de Bioqu�mica M�dica, Bl E-sl 38
City
Rio de Janeiro
Country
Brazil
E-mail
alandeirafernandez[at]yahoo.com.br
Website
http://www.bioqmed.ufrj.br/conteudo_view.asp?ID=120
Research Field
Physiology; cell biology
Award Year
2001
Country Of Origin
Brazil
Mentor Name
Barbara A. Block, Ph.D.

Research

Our research aims to compare the enzyme activity of Ca2 + - ATPase , from the sarcoplasmic reticulum/ endoplasm of skeletal and cardiac muscle of endothermic fish (blue marlin) and ectothermic (trout) at different temperatures. This enzyme plays a key role during excitation-contraction of muscle. During the process of muscle contraction, the concentration of cytoplasmic Ca2 + increases about 1,000 times, promoting muscle contraction. The basal levels of Ca2 + in the cytoplasm are restored due to the activity of this enzyme, which is responsible for active transport of Ca2 + from the cytoplasm into the sarcoplasmic reticulum at the expense of ATP hydrolysis, which promotes muscle relaxation.