Joaquin Espinosa, Ph.D.

Title
HHMI Early Career Scientist, Associate Professor
Department
Department of Molecular Cellular & Developmental Biology
Institution
University of Colorado
Address
Campus Box 347 UCB
City, State, Zip
Boulder, CO 80309
Country
United States
E-mail
Joaquin.Espinosa[at]Colorado.EDU
Website
https://mcdb.colorado.edu/directory/espinosa_j.html
Research Field
Genetics
Award Year
2000
Country Of Origin
Argentina
Mentor Name
Beverly Emerson, Ph.D.

Research

We study gene circuits of relevance to human cancer including the p53 tumor suppressor network, the oncogenic serum response network and the hypoxia response network. We use a multidisciplinary approach combining anything from biochemical assays to genetic screens in human cells. Example projects are: 1) Investigating the role of diverse transcriptional co-factors in cell type-, stimulus- and promoter-specific regulation within these transcriptional programs. 2) employing genetic screens to identify new regulators of the cellular response to p53 activation and the hypoxic response. 3) Functional proteomic analysis of the mitochondrial apoptotic pathway.