Juan Carlos Pina-Crespo, Ph.D.

Title
Scientist
Department
Del E Webb Neuroscience, Aging and Stem Cell Research Center
Institution
Sanford Burnham Medical Research Institute
Address
10901 North Torrey Pines Road
City, State, Zip
La Jolla, CA 92037
Country
United States
E-mail
pina-crespo[at]sanfordburnham.org
Website
http://myprofile.cos.com/pinacrespo
Research Field
Neuroscience
Award Year
1999
Country Of Origin
Venezuela
Mentor Name
Stephen F. Heinemann, Ph.D.

Research

Neuronal function and susceptibility to cell damage is dependent upon neurons expressing specific repertoires of glutamate receptors. The pattern of expression of these receptors can be regulated by ion channel activity. Abnormal patterns of expression of genes encoding glutamate receptor subunits belonging to the NMDA-receptor subfamily of ion channels have been described in a number of brain disorders. The aim of my research work is to investigate how the abnormal neuronal expression of particular subtypes of NMDA receptor-channels can affect glutamatergic neurotransmission and neurons susceptibility to cell death.