Susana Castro-Obregón, Ph.D.

Title
Assistant Professor
Department
Department of Neurodevelopment and Physiology
Institution
National Autonomous University of Mexico
Address
Circuito Exterior S/N
Colonia Ciudad Universitaria
City, Zip
D.F., 4510
Country
Mexico
Phone
(52)(55)5622-5676
E-mail
scastro[at]ifc.unam.mx
Website
www.ifc.unam.mx
Research Field
Neuroscience
Award Year
1998
Country Of Origin
Mexico
Mentor Name
Dale Bredesen, M.D.

Research

During development, the size and structures of organs are the consequence of a fine balance among cell proliferation, differentiation and death. Autophagy is a catabolic process, evolutionary conserved, implicated in all these cellular processes. It is induced by nutrients and growth factors limitation, allowing the cell to survive for longer periods by recycling components and eliminating damaged macromolecules and organelles. Autophagy dysregulation is a key factor in the onset of cancer, neurodegeneration, metabolic diseases, etc. and its efficiency is reduced with ageing. We study the molecular basis for autophagy regulation and its influence in cell fate, as well as its mechanism to extend lifespan. Recently, we conceived the hypothesis that autophagy could contribute to the morphogenesis of the nervous system.