Ramon O. Bernabeu, Ph.D.

Title
Associate Professor
Department
Department of Physiology
Institution
University of Buenos Aires
Address
C1121ABG
City
Buenos Aires
Country
Argentina
Phone
0541159509500 ext 2148
E-mail
rbernabeu[at]fmed.uba.ar
Website
http://www.ibcn.fmed.uba.ar/200_grupos-lab-neurobiologia-bernabeu.html
Research Field
Neuroscience
Award Year
1998
Country Of Origin
Argentina
Mentor Name
Frank M. Longo, M.D., Ph.D.

Research

Drug addiction is a chronically relapsing disorder characterized by compulsion to use one or more drugs of abuse coupled with inability to control drug intake. Drug craving and relapse are precipitated by re-exposure to a previously abused drug, an environment associated with prior drug use or a stressful life event. Over 80% of smokers in the U.S. want to quit, fewer than 5% succeed, indicating a high relapse for this drug. My current research addresses basic questions regarding the cellular, molecular and behavioral neurobiological changes induced by nicotine consumption, specifically during nicotine withdrawal and relapse. My specific project involves understand how nicotine-induced activation of nicotinic receptors could be linked to subunit composition and/or transmembrane protein-complex-mediated synaptic plasticity during nicotine withdrawal and relapse.