Simone Engelender, M.D., Ph.D.

Title
Associate Professor
Department
Department of Molecular Pharmacology
Institution
Technion-Israel Institute of Technology
Address
POB 9649, Bat Galim
City
Haifa
Country
Israel
E-mail
simone[at]techunix.technion.ac.il
Website
http://md.technion.ac.il/lecturers/lecturer_desc.asp?lecturerID=85&departmentID=6&contentCatID=4
Research Field
Neuroscience
Award Year
1996
Country Of Origin
Brazil
Mentor Name
Christopher A. Ross, M.D., Ph.D.

Research

We study the molecular mechanisms involved in Parkinson’s disease. We investigate how proteins involved in the disease, in special _-synuclein and synphilin-1 isoforms, form Lewy body-like inclusions. We also investigate how their ubiquitylation contributes to the formation of inclusions. We propose that ubiquitylation of synphilin-1 and _-synuclein represents a primary event for the formation of Lewy bodies and to pathogenesis of the disease.