Victor Manuel Baizabal Aguirre, D.Sc.

Title
Professor
Department
Department of Veterinary Medicine and Animal Husbandry
Institution
University Michoacana of San Nicolas de Hidalgo
Address
Posta Veterinaria
Km. 9.5 Carretera Morelia-Zinapecuaro
City
Morelia, Michoacan
Country
Mexico
Phone
+52 (443) 295 80 29 ext. 5
E-mail
baizabal[at]umich.mx
Website
http://www.cmeb.umich.mx/admin/1/
Research Field
Cell Biology
Award Year
1995
Country Of Origin
Mexico
Mentor Name
Julian I. Schroeder, Ph.D.

Research

Staphylococcus aureus is a major pathogenic bacteria that cause various diseases in humans such as osteomyelitis, endocarditis and pneumonia. All of these conditions involve inflammation. In dairy cattle, the bacterium is one of the most important causal agents of clinical mastitis. It has recently been reported that S. aureus invades and persists inside macrophages and in endothelial cells and epithelial cells. In my lab we are interested in understanding the cellular processes, and biochemical and molecular pathways involved in the internalization and intracellular survival of S. aureus in endothelial cells and macrophages of the mammary gland of cattle. For this, we have proposed analyze the role of components of the molecular pathways involved in signal transduction activated by the TLR receptors, TNFR1 and ILR1 and the mitogen-activated protein kinases JNK and p38. Our goal is to design biomolecular strategies to eradicate infections caused by this bacteria.