Manuel A. Kukuljan, Ph.D.

Title
Professor
Department
Institute for Biomedical Sciences
Institution
University of Chile
Address
Av. Independencia 1027
City
Santiago
Country
Chile
E-mail
kukuljan[at]med.uchile.cl
Website
http://neuro.med.uchile.cl/pags/fset_inv.html
Research Field
Neuroscience
Award Year
1991
Country Of Origin
Chile
Mentor Name
Eduardo Rojas, Ph.D.

Research

My laboratory is interested in understanding the mechanisms that underlay the determination and maintenance of functional neuronal phenotypes, in particular the regulation and expression of ion channels and other neuronal genes, and the role of ion channels in early development. Addressing these problems involves studies of cellular physiology, developmental biology, cell and molecular biology, with an emphasis on understanding phenomena in vivo in model organisms such as Xenopus laevis, and the zebrafish Danio rerio. The three main studies of the lab are 1) The function of the REST/NRSF transcription factors during development and maintenance of the vertebrate nervous system. 2) Expression and functional role of calcium channels during early development. 3) Regulation of the expression of neuronal sodium channels.