Antonio Carlos Oliveira Bruno, Ph.D.

Title
Professor and Director
Department
Department of Physics
Institution
Pontifical Catholic University of Rio de Janeiro
Address
Rua Marques de Sao Vicente 225
City
Rio de Janeiro
Country
Brazil
E-mail
acbruno[at]puc-rio.br
Website
www.fis.puc-rio.br/acbruno_ing.php
Research Field
Physics
Award Year
1991
Country Of Origin
Brazil
Mentor Name
Samuel J. Williamson, Sc.D.

Research

We are interested in developing new instruments and magnetic sensors for a new type of immunoassay where the reaction antigen-antibody is used for detecting viruses, bacteria, cancerous cells, etc. Usually immunoassays use markers that consist of particles in the nanometer range, having a magnetic nucleus and layers which contain antibodies and fluorescent or enzymatic properties. Traditionally, the markers are detected through their layers properties, and the amount of antigens linked to the antibodies can be estimated. However, this method has limitations due to instability of the fluorescent and enzymatic layers. Recently, Superconducting Quantum Interference Devices (SQUIDs) have been applied to immunoassays to quantify these markers by measuring the magnetization of their nucleus. Due to the extraordinary capacity of the SQUID for measuring magnetic flux, this technique has the potential to increase the sensitivity and the dynamic range of the assays, leading to an early diagnosis of several important pathologies.