Gloria A. Brar, Ph.D.

Title
Assistant Professor
Department
Department of Molecular and Cell Biology
Institution
University of California, Berkeley
Address
626 Barker Hall
Campus code 3202
City, State, Zip
Berkeley, CA 94720
Phone
(510) 664-7100
E-mail
gabrar[at]berkeley.edu
Website
www.brarlab.org
Research Field
Molecular Biology
Award Year
2016

Research

My research aims to unravel the gene regulatory programs that govern meiosis—the specialized cell division that results in the formation of gametes. As a postdoctoral fellow, I discovered several surprising properties of meiotic gene regulation in yeast, including meiosis-specific synthesis of proteins from a set of more than 2,500 new genes that are smaller than the size cutoff used for traditional genome analyses. These genes encode proteins that are, on average, less than one-quarter the size of the average yeast protein and the role they play in meiosis is currently not understood. I hope to identify the functions of these novel gene products by a set of genetic, biochemical, and computational approaches, including precisely altering their timing of expression and determining the effects on meiotic progression. This work will shed light on how a previously overlooked class of genes impacts a fundamental developmental process and could more broadly identify new universal principles by which proteins can function and by which genomes are decoded.