Alexander A. Gimelbrant, Ph.D.

Title
Assistant Professor
Department
Cancer Biology
Institution
Dana-Farber Cancer Institute, Harvard Medical School
Address
450 Brookline Avenue
City, State, Zip
Boston, MA 02115
Phone
(617) 582-7326
E-mail
gimelbrant[at]mail.dfci.harvard.edu
Website
http://research4.dfci.harvard.edu/gimelbrantlab/Main.html
Research Field
Molecular Genetics, Epigenetics
Award Year
2010

Research

My laboratory investigates how establishment of cell identity can be determined by the choice of which allele, maternal or paternal, will be expressed in a given cell lineage. We have shown that this type of allelic choice occurs with many hundreds of human genes, creating an extraordinary epigenetic diversity in cell populations, such as those in the immune and nervous system. We use and develop a variety of approaches, including allele-specific arrays and whole-transcriptome next-generation sequencing, in order to build a comprehensive map of allele-specific expression and the correlated chromatin states. This effort is under way in both human and mouse cells to gain an insight into the evolutionary context of allelic silencing.