Holger Sondermann, Ph.D.

Title
Associate Professor
Department
Molecular Medicine
Institution
Cornell University
Address
College of Veterinary Medicine
City, State, Zip
Ithaca, NY 14853
Phone
(607) 253-3318
E-mail
hs293[at]cornell.edu
Website
http://sondermannlab.vet.cornell.edu/
Research Field
Microbiology
Award Year
2008

Research

My lab is interested in deciphering the basic regulatory principles in signal transduction networks on a molecular level, focusing on growth factor receptor signaling. In particular, we study the role of scaffolding proteins and other regulators signal transduction in this pathway, using a combination of X-ray crystallography, biophysical and cellular approaches. Scaffolds, which serve as docking hubs for the signaling switches, provide specificity and higher-order control in signaling reactions. Understanding the architecture, mode of action and regulation of these processes will elucidate how cells respond to various inputs producing distinct outputs by using a limited set of molecules.