José M. Barral, M.D., Ph.D.

Title
Assistant Professor
Department
Department of Neuroscience and Cell Biology
Institution
University of Texas Medical Branch at Galveston
Address
301 University Boulevard
Research Building 17, Rm. 5.212.C (L12391)
City, State, Zip
Galveston, TX 77555-0620
Phone
(409) 747-2180
E-mail
jmbarral[at]utmb.edu
Website
http://www.utmb.edu/ncb/faculty/BarralJose.asp
Research Field
Biochemistry
Award Year
2006

Research

A number of human diseases are known to result, directly or indirectly, from aberrant protein folding reactions. In addition to loosing their normal function, misfolded polypeptides may form toxic species, may exert dominant negative effects, or may not reach their proper cellular location. Recently, a direct involvement of molecular chaperones in human disorders has become increasingly evident. A major area of research in my laboratory is to study proteins with similarities to molecular chaperones that, when mutated, lead to neurodegenerative disorders. Expression of eukaryotic proteins in bacterial hosts often results in misfolding and aggregation, which has placed great limitations on their recombinant production. Another area of my research focuses on the mechanisms underlying the inability of the bacterial cytosol to support efficient folding of eukaryotic multi-domain proteins. We have found that bacteria and eukaryotes utilize markedly different pathways for de novo protein folding, and have begun to identify the molecules involved in these processes.