Jenny E. Gumperz, Ph.D.

Title
Associate Professor
Department
Medical Microbiology and Immunology
Institution
University of Wisconsin-Madison
Address
Microbial Sciences Building Rm 4305
1550 Linden Drive
City, State, Zip
Madison, WI 53706-1521
Phone
(608) 263-6902
E-mail
jegumperz[at]wisc.edu
Website
http://medmicro.wisc.edu/people_faculty_profile.php?id=jegumperz&view=intro
Research Field
Immunology
Award Year
2005

Research

My lab studies a population of regulatory T lymphocytes called NKT cells. Whereas most T cells recognize peptide antigens that derive from non-self proteins and are presented at the cell surface by MHC molecules, NKT cells are activated by lipid and glycolipid antigens presented by CD1d molecules. What particularly interests us about NKT cells is that they can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge. The central focus of my lab is to understand how this autoreactivity contributes to immune regulation.