Franck Polleux, Ph.D.

Title
Professor
Department
Department of Neuroscience
Institution
Columbia University
Address
630 West 168th Street
P&S Room 10-435
City, State, Zip
New York, NY 10032
Phone
(212) 342-4413
E-mail
fp2304[at]columbia.edu
Website
http://www.columbia.edu/~fp2304
Research Field
Neuroscience
Award Year
2005

Research

Our lab is studying the developmental mechanisms patterning connections in the cerebral cortex. We are specifically interested in identifying the signaling pathways controlling three important and inter-related aspects of cortical neurons differentiation: migration, axon pathfinding and dendritic differentiation. In order to analyze the role of specific signaling pathways in the specification of cortical connectivity, we are combining a wide array of molecular and cellular approaches such as: (1) biochemistry and proteomics, (2) time-lapse confocal microscopy, (3) calcium-imaging, (4) ex vivo and in utero electroporation, (5) in vitro co-culture assays and (6) analysis of mice presenting targeted gene deletion or promoter-driven GFP expressing mice.