Toshio Tsukiyama, D.V.M., Ph.D.

Title
Member
Department
Division of Basic Sciences
Institution
Fred Hutchinson Cancer Research Center
Address
1100 Fairview Avenue N.
Mail Stop A1-162
City, State, Zip
Seattle, WA 98109-1024
Phone
(206) 667-4996
E-mail
ttsukiya[at]fhcrc.org
Website
http://research.fhcrc.org/tsukiyama/en.html
Research Field
Molecular Biology
Award Year
1998

Research

In the Tsukiyama Lab, we are interested in finding out how chromatin is regulated. Our current interest centers around the functions of multi-subunit complexes containing ISWI. The complexes in this class are highly conserved from yeast to humans, and use the energy of ATP hydrolysis to move nucleosomes around in vitro. However, it is poorly understood what they do in vivo. We believe that we will be able to learn new principles in chromatin regulation by finding out how ISWI complexes function. We are taking advantage of many tools for molecular genetic and biochemistry available in our model system, S. cerevisiae.