Thomas L. Ortel, M.D., Ph.D.

Title
Director, Anticoagulation Management Service
Department
Division of Hematology
Institution
Duke University
Address
Box 3422, Medical Center
City, State, Zip
Durham, NC 27710
Phone
(919) 684-5350
E-mail
ortel001[at]mc.duke.edu
Website
http://medicine.duke.edu/faculty/details/0113434
Research Field
Molecular Biology
Award Year
1995

Research

My research program investigates the molecular mechanisms whereby various congenital and acquired abnormalities result in 'dysfunctional' hemostasis (i.e., hemorrhage or thrombosis) to better understand the molecular mechanisms and interactions that are necessary for normal hemostasis. We are particularly interested in the mechanisms whereby antibodies and other inhibitors can interfere with normal hemostatic mechanisms. Several projects extensively overlap and focus on the assembly and function of procoagulant (e.g., factor X-ase and prothrombinase) and anticoagulant (e.g., activated protein C complex) phospholipid membrane-dependent complexes.