Stephen Buratowski, Ph.D.

Title
Professor
Department
Department of Biological Chemistry and
Institution
Harvard University
Address
Building C1 Room 210
240 Longwood Avenue
City, State, Zip
Boston, MA 2115
Phone
(617) 432-0696
E-mail
steveb[at]hms.harvard.edu
Website
https://buratowski.hms.harvard.edu/
Research Field
Genetics; Molecular Biology
Award Year
1995

Research

Our lab studies eukaryotic gene expression. We are concentrating on three areas: (A) the functions and interactions of the RNA polymerase II (RNApII) basal transcription factors, (B) the communication between chromatin and the transcription machinery, and (C) mRNA processing enzymes and their interactions with RNApII. Using the yeast Saccharomyces cerevisiae, a combination of biochemical and genetic techniques are being brought to bear on these questions. Several dozen proteins are required simply to initiate transcription, and many more are required for processes linked to transcription. Therefore, it is now necessary to decipher the functions of each of the individual factors.