Marcia B. Goldberg, M.D.

Title
Associate Professor
Department
Department of Immunology and Infectious Diseases
Institution
Massachusetts General Hospital, Harvard University
Address
65 Landsdowne Street
City, State, Zip
Cambridge, MA 2139
Phone
(617) 768-8740
E-mail
mgoldberg1[at]partners.org
Website
http://www.massgeneral.org/goldberglab/
Research Field
Microbiology
Award Year
1994

Research

Our lab focuses on two related scientific ideas; the molecular nature of interactions between microbial pathogens and the host, with an emphasis on the intracellular human pathogen Shigella, and the molecular nature of bacterial cellular organization, and its impact on interactions with host cells. Specifically, we are investigating 1) the molecular mechanisms by which bacteria establish polarity 2) how Shigella spread by inducing the assembly of an actin tail at the bacterial pole 3) how Shigella form protrusions that allow for intercellular spread 4) how the autotransporter family of secreted proteins are translocated across the bacterial membranes and periplasm