Didier Trono, M.D.

Title
Professor
Department
School of Life Sciences
Institution
Ecole Polytechnique Fédérale de Lausanne (EPFL)
Address
SV-GHI-LVG, Station 19
CH-1015
City, Zip
Lausanne, 01015
Country
Switzerland
Phone
+41 (0) 21 693 1751
E-mail
didier.trono[at]epfl.ch
Website
http://tronolab.epfl.ch/
Research Field
Virology
Award Year
1992

Research

Retroelements constitute important evolutionary forces for the genome of higher organisms, yet their uncontrolled spread, whether from endogenous loci or within the context of viral infections, can cause diseases such as cancer, hepatitis and AIDS. Correspondingly, a variety of host-encoded activities limit this process, belonging to a line of defense commonly called intrinsic or innate immunity, which notably contributes to taming endogenous retroelements and to restricting the cross-species transmission of retroviruses. Our work aims at characterizing the relationship between retroelements and their hosts, which has recently led us to become more generally interested in epigenetic mechanisms regulating the expression of mammalian genomes.