Rory M. Marks, M.B.B.S.

Title
Associate Professor
Department
Department of Internal Medicine
Institution
University of Michigan
Address
Medical Science Research Building II
1150 W Medical Center Drive Room 3560
City, State, Zip
Ann Arbor, MI 48109-0680
Phone
(734) 936-3257
E-mail
rmarks[at]umich.edu
Website
http://www2.med.umich.edu/departments/Rheumatology/index.cfm?fuseaction=rheumatology.facultyBio&individual_id=35953&um_department=Internal%20Medicine
Research Field
Immunology
Award Year
1991

Research

Our research is focused on understanding the role of the vasculature in mediating inflammation, and in causing tissue injury in autoimmune diseases. We are exploiting viruses that exhibit vascular tropism to identify novel molecules expressed by vascular endothelial cells. Dengue virus causes a febrile illness in humans that is associated with considerable vascular pathology. We hypothesized that identification of the target cell receptor used by dengue virus could lead to identification of novel vascular endothelial cell receptors. We identified the dengue receptor on some cells as a novel highly sulfated form heparan sulfate glycosaminoglycan. However, the endothelial cell receptor is a distinct structure, an o-linked mucinous glycoprotein. He also identified 3 distinct glycan-binding motifs in the dengue virus envelope protein, and considerable evidence indicates that these regions account for target cell binding activity. Compounds have been identified that inhibit dengue virus infection of target cells. We are now pursuing this project both as a broad investigation into dengue virus pathobiology, as well as attempting to fully characterize and identify the vascular endothelial cell receptor for dengue virus.