Daniel E. Gottschling, Ph.D.

Title
Member
Department
Division of Basic Sciences
Institution
Fred Hutchinson Cancer Research Center
Address
1100 Fairview Avenue N
Mailstop A3-025
City, State, Zip
Seattle, WA 98109-1024
Phone
(206) 667-4494
E-mail
dgottsch[at]fhcrc.org
Website
http://research.fhcrc.org/gottschling/en.html
Research Field
Genetics
Award Year
1991

Research

Our laboratory uses the budding yeast Saccharomyces cerevisiae as a model system to investigate fundamental questions in biology. One of our current areas of interest is understanding the striking link between increasing age and the incidence of cancer in humans. A hallmark of cancer, genomic instability, is observed in all types of organisms including yeast. We recently discovered that as yeast cells enter the middle-to-late period of their replicative lifespan, they switch to a state of high genomic instability that persists until death. We believe this change represents a fundamental transition in many aging cells and thus are taking a number of approaches to understand the mechanism underlying this phenomenon.