Yusuf A. Hannun, M.D.

Title
Joel Kenny Professor and Director
Department
Stony Brook Cancer Center
Institution
Stony Brook University
Address
Health Sciences Center, L-4, 182
City, State, Zip
Stony Brook, NY 11794
Phone
(631) 444-8067
E-mail
yusuf.hannun[at]stonybrook.edu
Website
http://medicine.stonybrookmedicine.edu/medicine/faculty/hannun
Research Field
Biochemistry
Award Year
1988

Research

Our laboratory is focused on studies on bioactive lipids, with a special emphasis on sphingolipids. These studies have allowed us to propose a critical role for sphingolipids in eukaryotic stress responses. We are interested in understanding how sphingolipid metabolism is regulated under various conditions and in response to extracellular stimuli. We are also interested in defining the functions of bioactive sphingolipids, including sphingosine and ceramide.

We perform our studies in human cancer cells as well as in yeast as a model organism. Our current projects include studies on 1)Sphingolipid Network in Yeast 2) Regulation and Function of Neutral Sphingomyelinases 3) Regulation and Function of Acid Sphingomyelinase 4) Ceramide activated protein phosphatases 5) Protein Kinase C 6) Neutral Ceramidase