Charles N. Serhan, Ph.D.

Research

The research undertaken in the Serhan laboratory focuses on structural elucidation of bioactive molecules. The overall mission is “To identify novel pathways and cellular targets critical in regulating neutrophil-mediated inflammation and to establish the templates for physiologic small molecule-based interventions.” In the Center for Experimental Therapeutics and Reperfusion Injury (CET&RI), the overarching mission is to define the molecular mechanisms underlying reperfusion injury and to identify novel therapeutic interventions that can prevent cell injury. The most recent studies undertaken in the Serhan laboratory focus on structural elucidation of novel molecules and pathways that serve as pro-resolving and/or endogenous anti-inflammatory chemical signals. The current focus is on elucidating lipid-derived as well as other autacoids that are involved in intracellular signaling and cell-cell signaling. We study acute inflammation in murine models as well as second organ injury following reperfusion.