Michael B. McKeown, Ph.D.

Title
Professor
Department
Division of Biology and Medicine
Institution
Brown University
Address
69 Brown Street
G-J363
City, State, Zip
Providence, RI 2912
Phone
(401) 863-9807
E-mail
Michael_McKeown[at]Brown.edu
Website
https://vivo.brown.edu/display/mmckeown
Research Field
Genetics
Award Year
1986

Research

My lab is interested in the way genes interact to control interesting processes in complex organisms. Of particular interest at the moment is dissection of the genetic, molecular and neural bases of behavior, with sexual behavior serving as a model. An unexpected but exciting spin off from this work has been the identification of genes involved in age-dependent behavioral and neural degeneration. Sexual behavior in Drosophila involves stereotypic behaviors in both sexes. A screen based on alterations in an easily scored female behavior has yielded a number of potentially interesting loci, with two genes being substantially characterized. Mutations in both of these affect both sexes, altering sex-specific behavior and sex-specific neural development. Both genes encode DNA binding transcriptional regulators with limited patterns of expression within the brain and CNS at the time when sex-specific behaviors are established. The regulatory regions of these genes, and alterations within their proteins are currently being used to dissect the nature and function of the sex-specific nervous system. As part of the studies on sexual behavior, two genes were identified that give rise to age-dependent behavioral or neural degeneration. Mutations in one of these loci lead to early death accompanied by massive apoptotic cell death in the brain. Mutations in the other gene do not shorten life span under optimal laboratory conditions but lead to alterations in sexual and non-sexual behaviors as well as general loss of mobility and control of body carriage. Although the brains of these animals appear grossly normal, the structural integrity of the brain appears to be diminished. Candidate loci for genetic interaction with this gene have been identified, as have related human genes.