Glen R. Nemerow, Ph.D.

Title
Professor
Department
Department of Immunology and Microbial Science
Institution
Scripps Research Institute
Address
10550 North Torrey Pines Road
Mail drop IMM19
City, State, Zip
La Jolla, CA 92037
Phone
(858) 784-8072
E-mail
gnemerow[at]scripps.edu
Website
http://www.scripps.edu/ims/nemerow/
Research Field
Virology
Award Year
1986

Research

Human adenoviruses are a major cause of acute respiratory, intestinal and ocular infections. However, these viruses have also served as valuable tools with which to investigate fundamental cell and molecular biological processes. Research in the Nemerow lab is focused on gaining a better understanding of adenovirus interactions with host cells. We investigate basic mechanisms involved in virus attachment, internalization, membrane penetration and nuclear localization. A major focus of these studies is the signaling events initiated by cell integrins that promote adenovirus endocytosis. Collaborations with structural biologists, cell biologists, and protein chemists play a significant role in these investigations. Fundamental knowledge gained from virus-host cell interaction studies is exploited for the design of novel viral vectors with increased capacity to deliver therapeutic genes to specific cell types including endothelial, vascular smooth muscle cells, photoreceptors, and bone-marrow derived progenitor cells.