George M. Shaw, M.D., Ph.D.

Title
Professor
Department
Department of Medicine
Institution
University of Pennsylvania
Address
409 Johnson Pavilion
3610 Hamilton Walk
City, State, Zip
Philadelphia, PA 19104
Phone
(215) 746-8514
E-mail
shawg[at]upenn.edu
Website
http://www.med.upenn.edu/apps/faculty/index.php/g275/p8419054
Research Field
Virology
Award Year
1986

Research

Our laboratory is studying the molecular biology and pathogenesis of human retroviruses, including HIV-1, HIV-2, HTLV-I, and HTLV-II. Using oligonucleotide-directed site-specific mutagenesis, we are examining the structure-function properties of conserved gene products of the HIV-1/2 family involved in viral attachment, entry, and replication. Using a combination of viral culture and PCR-mediated gene amplification techniques, we are also examining viral properties including genotypic variation, viral burden, and replication that affect viral pathogenesis in vivo. The overall goal of these studies is to elucidate viral pathogenesis at the molecular level and to develop novel approaches to disease prevention and treatment.