Barbara E. Ehrlich, Ph.D.

Title
Professor
Department
Department of Pharmacology
Institution
Yale University
Address
Sterling Hall of Medicine Room B207
333 Cedar Street
City, State, Zip
New Haven, CT 06520-8066
Phone
(203) 737-1158
E-mail
barbara.ehrlich[at]yale.edu
Website
http://medicine.yale.edu/labs/hermeneutics/www/
Research Field
Cell Biology
Award Year
1986

Research

My laboratory is interested in how cells regulate their intracellular calcium concentration. We have focused on one aspect of this process, the release of calcium from intracellular stores. We study the two classes of calcium release channels known to exist inside virtually all cells - the InsP3-gated channel and the ryanodine receptor/channel - and we have identified a new intracellular calcium release pathway. Our goal is to understand how the function of these channels is regulated by processes within the cell. These data will form the background for our long-term interest, how calcium release channel function is altered in disease. For example, a binding protein for immunosuppressive drugs is associated with these channels. We hypothesize that some side effects of immunosuppressive therapy (e.g., neurological seizures and heart failure) are related to drug-induced functional changes in channel activity. Our studies will test our hypotheses and hopefully, will lead to suitable treatment regimens.